Progress in the studies on extra-islet effects of incretin
10.3760/cma.j.issn.1000-6699.2011.06.025
- VernacularTitle:肠促胰素的胰腺外作用研究进展
- Author:
Linong JI
- Publication Type:Journal Article
- Keywords:
Incretin;
Glucagon-like peptide-I;
Glucose-dependent insulinotropic polypeptide;
Diabetes mellitus,type 2
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(6):后插1-4
- CountryChina
- Language:Chinese
-
Abstract:
Incretin is defined as an intestinal hormone released in response to nutrient ingestion, which potentiates the glucose-induced insulin response. In human body, the incretin's effect is mainly induced by two peptide hormones, glucagon-like peptide-I (GLP-I)and glucose-dependent insulinotropic polypeptide (GIP). In order to fully evaluate the clinical advantages of novel agents based on incretin, this review introduces the islet actions of incretin in brief, and mainly focuses on the extra-islet effect of incretin.
