Relation of the perigastric extracapsular lymph node spread to prognosis of patients with gastric carcinoma
10.3760/cma.j.issn.1673-4203.2011.07.004
- VernacularTitle:胃癌转移淋巴结被膜外扩散和患者预后的关系
- Author:
Youfu GAO
;
Hao SUN
;
Hong CHEN
;
Xueyong WU
;
Bojian JIANG
- Publication Type:Journal Article
- Keywords:
Gastric neoplasms;
Prognosis;
Lymph node metastasis;
Extracapsular lymph node spread
- From:
International Journal of Surgery
2011;38(7):441-444,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of the current study was to investigate the prognostic value of extracapsular lymph node spread in gastric cancer patients and to find correlations with clinicopathological parameters.Methods Clinicopathological data of 131 gastric cancer patients who underwent gastrectomy with lymphadenectomy were analyzed retrospectively. The number of metastatic lymph nodes with extracapsular spread were determined. Multivariate analysis was performed to find the clinical prognosis affecting extracapsular lymph node involvement. Results Seventy-eight patients (59.5%)had perigastric lymph node metastasis. Fortysix cases were detected extracapsular lymph node involvement. The 5-year cumulative survival rate for patients with extracapsular lymph node spread was 13. 5% , while 32 patients with lymph node metastasis but without extracapsular involvement had a 5-year survival rate of 39.3%. The survival rate decreased significantly with the increase of extracapsular lymph node involvement(P =0.001). Extracapsular lymph node involvement was significantly associated with the higher number of metastatic lymph nodes, the location of lymph node metastasis, tumor invasion depth and distant lymph node metastasis. In the multivariate analysis, extracapsular lymph node spread also remained as an independent prognostic factor(P =0.003). Conclusions Extracapsular lymph node involvement is a convenient and reliable prognostic index, and is an independent prognostic factor in gastric cancer patients. In future staging systems for gastric cancer, extracapsular lymph node involvement should be considered, be pathologically checked and reported in order to determine extracapsular spread status.
