The expression of connective tissue growth factor, collagen I and collagen Ⅲ in sacroiliac joint of patients with spondyloarthropathy
10.3760/cma.j.issn.1007-7480.2011.05.011
- VernacularTitle:结缔组织生长因子及I型和Ⅲ型胶原在脊柱关节病骶髂关节组织中的表达
- Author:
Qingwen WANG
;
Huifen ZENG
;
Caihong YANG
;
Yueming CAI
;
Cheng CHEN
;
Weihua YIN
;
Guangyin YU
;
Guangling CAI
;
Huiyao LAN
- Publication Type:Journal Article
- Keywords:
Crowth substances;
Collagen type Ⅰ;
Collagen type Ⅲ;
Spondyloarthropathy;
Saero-iliac joint
- From:
Chinese Journal of Rheumatology
2011;15(5):329-331,后插1
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of connective tissue growth factor(CTGF),coll agen I and collagen Ⅲ in sacroiliac joint(SIJ)of patients with spondyloarthropathy(SpA).Methods Thirty patients with SpA,including 17 patients with grade Ⅱ saeroiliitis and 13 patients with grade Ⅰ sacroiliitis,were performed on CT guided needie biopsy of SIJ.After sacroiliitis were confirmed by staining with hematoxylin and eosin in sacroiliac joint tissue sample,immunohistochemical assay was performed to determine the expression of CTGF,collagen Ⅰ and collagen Ⅲ in sacroiliac ioint tissue.Univariate Chi-square test was used for data comparison between multiple groups and t-test was used for two group data comparison.Results Contrast to healthy controls,CTGF were found upexpressed on the cytoplasm of inflammatory cells in pannus and bone marrow of sacroiliac tissue samples of patients with SpA,while collagen I and collagen Ⅲ were found up-expressed in bone,cartilage and ligament tissue[(57.9±42.4)/HP vs(2.7±2.5)/HP P<0.05,0.298±0.080 vs 0.044±0.024 and 28.254±41.165 vs 0.105±0.054.P<0.05 respectively].Conclusion CTGF,collagen Ⅰ and collagen Ⅲ are up-expressed in SIJ of SpA patients.CTGF may play an important role in articular cartilage fibrosis and ossification of SpA.
