The effect of ω-3 polyunsaturated fatty acid on immune function, infection and surgery ratio in severe acute pancreatitis patients
- VernacularTitle:鱼油对重症急性胰腺炎病人免疫功能和临床预后的影响
- Author:
Xinying WANG
;
Liya PAN
;
Weiqin LI
;
Ning LI
- Publication Type:Journal Article
- Keywords:
Severe acute pancreatitis;
ω-3 fatty acid;
Fish oil;
Immune function
- From:
Parenteral & Enteral Nutrition
2009;16(6):321-323,327
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate whether ω-3 fatty acid supplementation affects immune function, infection and surgery ratio in severe acute pancreatitis patients. Methods: Fifty-six severe acute pancreatitis patients were prospectively enrolled and were randomly assigned to receive total parenteral nutrition (TPN) for 5 days in a double-blinded manner with either soybean oil (SO) or fish oil (FO) supplementation. The level of IL-10 and HLA-DR expression were measured before TPN and on the sixth day after starting TPN. The clinical outcomes such as infection and surgery ratio were recorded. Results % Patients treated with ω-3 FA had significantly higher IL-10 concentration and better HLA-DR expression during the observation period. Although there was no significant difference between two groups, the ratio of infection and surgery ratio had a trend to decrease in the study group. Conclusion: TPN supplemented with ω-3 FA improves anti-inflammatory cytokine and immune function in SAP patients. It also leads to the attenuated risk of infection and surgery ratio.
