The impact of fast track surgery on host cell-mediated immunity and inflammatory responses for colorectal cancer patients
- VernacularTitle:结直肠癌病人应用加速康复外科术后炎症反应和免疫功能的变化
- Author:
Haizhi WANG
;
Zhiwei JIANG
;
Zhiming WANG
;
Yang BAO
;
Xingxing LIU
;
Qiang LENG
;
Gang WANG
;
Lifei XIE
;
Jieshou LI
- Publication Type:Journal Article
- Keywords:
Fast track surgery;
Colorectal cancer;
Cell-mediated immunity;
Inflammatory response
- From:
Parenteral & Enteral Nutrition
2009;16(4):195-196,200
- CountryChina
- Language:Chinese
-
Abstract:
Objective: The aim of this study was to evaluate the impact of fast track surgery on host cell-mediated immunology and inflammatory responses in colorectal cancer patients.Methods: Sixty colorectal cancer patients were prospectively divided into fast track surgery(FTS)group(n=30)and conventional perioperative care group(n=30).In addition to clinical parameters(recovery of gastrointestinal function,complication rates and postoperative length of stay), the parameters of perioperative cell-mediated immunology function,and the serum level changes of CRP and IL-6 were determined.Results: FTS group was associated with a significantly shorter postoperative hospital stay compared with conventional care group(P<0.05).Serum concentration of CRP and IL-6 in FTS group were lower(P<0.05) than in the conventional care group on postoperative day(POD) 1 and POD 3(P<0.05).CD4/CD8 ratio in FTS group were higher(P<0.05) than in the conventional care group on postoperative day(POD)1 and POD 3(P<0.05).Conclusion: Fast track surgery for colorectal cancer patients can preserve cell-mediated immunity and control inflammatory responses when compared with conventional postoperative care.
