Expression of p16, FHIT genes in cervical carcinoma and its clinical significance
10.3760/cma.j.issn.1006-9801.2011.06.005
- VernacularTitle:P16、脆性组氨酸三联体基因在子宫颈癌中的表达及其临床意义
- Author:
Xiaoyuan YU
;
Meizhen WAN
;
Yuxing YANG
;
Yanfeng HOU
;
Xiaowei CHENG
;
Liping DONG
;
Li CHENG
;
Ya CHEN
- Publication Type:Journal Article
- Keywords:
Cervical intraepithelial neoplasia;
Uterine cervical neoplasms;
pl6 gene;
FHIT
- From:
Cancer Research and Clinic
2011;23(6):376-378,383
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of pl6, FHIT genes in cervical carcinoma and its clinical significance. Methods By immunohistochemistry SP method, the expression of pl6, FHIT in different 118 cases of cervical lesions were detected and the results were analyzed in combination with clinical pathological features. Results Of 118 patients, 15 cases suffered cervicitis;38 cases took place cervical tumor-like changes;65 cases caught cervical cancer. p16 expression rates were 0, 33.3 %, 70.0 %, 87.5 %,and 92.3 % respectively;while FHIT expression rates were 73.3 %, 75.5 %, 60.0 %, 37.5%, and 30.8 % respectively. Compared with cervicitis, pl6 and FHIT expression rates in the cervix tumor-like changes,cervical carcinoma had significant difference (P <0.05). There was positive correlation in protein expression between p16 and FHIT (x2 =33.33, P <0.001). Conclusion Combination of p16, FHIT detection can be used as early diagnostic tool of cervical lesions and cervical cancer markers;meanwhile, the method can serve as a clinical evaluation of tumor biological behavior and prognosis of auxiliary indexes.
