PET-CT imaging preliminary study based on VX2 rabbit xenografts model

VernacularTitle:应用兔VX2移植瘤模型进行正电子发射断层显像-计算机体层成像的初步研究
Author: Gang TI ; Ming ZHAO ; Hongxing JIN ; Yawei LI ; Yuexing FAN ; Min ZHANG
Publication Type:Journal Article
Keywords: Rabbits; Xenografts; Model; animal; PET-CT
From: Cancer Research and Clinic 2011;23(7):477-478,482
CountryChina
Language:Chinese
Abstract: Objective To establish the model of VX2 soft tissue xenograft in rabbit, and choose the best time for PET-CT imaging. To analyze the result of the imaging with semi-quantitative, and evaluate the feasibility of the study with VX2 soft-tissue tumor model in rabbit for PET-CT imaging. Methods 20 Japanese white rabbits were successfully implanted with VX2 tumors in thighs by the injection of tissue mass suspension.Then they were scanned with PET-CT after the diameter of the tumor is ＞2 cm. Results The diameter of the tumor＞2 cm at 14 d post implant. The average volume of tumor was (114.57±9.87) cm3.The average SUVmax of tumor's and normal tissue's in the other thigh was 5.85±0.92 and 0.22±0.09 (t=27.03, P＜0.01). SUVmax was not associated with tumor volume (r=0.02, P=0.93).Conclusion The imaging of VX2 soft tissue xenograft is clear by clinic PET-CT, and it is suitable for the study of PET-CT.PET-CT imaging performed at 14 d post implantation had the highest imaging quality.