Study of the protective effect of salvia miltiorrhiza ennoblement for enteral nutrition on intestinal mucosa in MODS model rats
- VernacularTitle:丹参强化肠内营养对大鼠多器官功能障碍保护作用的研究
- Author:
Xiaorong LIU
;
Jie XU
;
Xinsheng REN
;
Jing WANG
- Publication Type:Journal Article
- Keywords:
Endotoxin;
Salvia mihiorrhiza;
Enteral nutrition;
S-MODS;
Cytokine
- From:
Parenteral & Enteral Nutrition
2009;16(4):234-236,238
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the protective effect of salvia miltiorrhiza for enteral nutrition in S-MODS model rats.Methods: 70 Wistar rats were randomly divided into four groups: control group (n=10), model group (n=20), nutrition fibre group (n=20) and salvia miltiorrhiza for enteral nutrition group (n=20) . The experiment period was 12 days. At the end of experiment, blood routine, biochemistry index (ALB, AST, ALT, BUN, Cr, CK and CK-MB), the concentrations of IL-6,TNF-α and IL-1β were measured. Results: The model was successful by clinical manifestation,blood routine and pathology. The clinical symptom was improved, blood routine and pathology damage were relieved in salvia miltiorrhiza group. The concentrations of IL-6, TNF-α and IL -1 in salvia miltiorrhiza group were lower than model group and nutrition fibre group(P<0.05).Conclusions: Salvia miltiorrhiza for enteral nutrition could prevent gut function damage,protect intestinal mucosa and decrease the concentrations of pro-inflammatory cytokines.
