Influence of exercise training and angiotensin-converting enzyme inhibitor on blood pressure, aortic compliance and cardiovascular tissue in spontaneously hypertensive rats
10.3969/j.issn.1008-0074.2012.05.02
- VernacularTitle:运动和血管紧张素转换酶抑制剂干预对自发性高血压大鼠血压和心血管组织的影响
- Author:
Qi GUO
;
Jiazhong WANG
- Publication Type:Journal Article
- Keywords:
Exercise;
Angiotensin-converting enzyme inhibitors;
Rats, inbred SHR
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2012;21(5):456-462
- CountryChina
- Language:English
-
Abstract:
Objective: To explore influence of exercise training and angiotensin-converting enzyme inhibitor (perindopril) on blood pressure, aortic compliance and cardiovascular tissue structure in spontaneously hypertensive rats (SHR). Methods: A total of 38 SHR aged seven weeks were divided into control group (C group, n=9), exercise group (Exe group, n=9), perindopril group (Per group, n=10) and perindopril + exercise group (Per＋Exe group, n=10). SHRs were observed for eight weeks, and tail-cuff method was used to measure systolic blood pressure（SBP）once a week. When rats were 15 weeks old, regression line（once linear function）was obtained by single regression analyzing the relation between blood pressure and pulse wave velocity（PWV）. The b of this once linear function was used as index of aortic compliance（there was negative relationship between b and aortic compliance）. The left ventricular mass （LVM）/body weight（BW）was used to evaluate ventricular thickening, and aortic weight （AO）/ BW was regard as index of vascular thickening. Results: Compared with C group, SBP of Exe group significantly decreased on 12 weeks old (P<0.01) and 13 weeks old (P<0.05), but decrease of SBP was no significant on 14 weeks old（P＞0.05）. SBP of Per group and Per+ Exe group on eight weeks old immediately decreased to level of seven weeks old (P<0.0001),but there was no significant difference between the two group（P>0.05）. On 15 weeks old, the LVM/BW [(2.19±0.36) mg/g, (2.16±0.32) mg/g ] and AO/BW [(0.20±0.01) mg/g, (0.19±0.01) mg/g] of Per group and Per+ Exe group significantly decreased compared with C group [(2.95±0.58) mg/g, (0.26±0.01) mg/g], P<0.05 all, but there was no significant difference in these indexes between Per group and Per+ Exe group and between C group and Exe group（P＞0.05 both）. The b （index of aortic compliance）were [（C group ：（21.2±1.2）, Exe group：（20.5±1.4）, Per group：（14.8±1.6），Per＋Exe group：（15.0±1.3）] respectively, there was no significant difference between Per group and Per+ Exe group and between C group and Exe group（P＞0.05 both）. Conclusion: The exercise training of eight weeks possesses certain lowering blood pressure tendency, but no significant influence yet for aortic compliance and cardiovascular tissue structure in spontaneously hypertensive rats.
- Full text:P020130113405778594533.doc
