Study for serum levels of hepatocyte growth factor and soluble intercellular adhesion molecule-1 in patients with hypertension
10.3969/j.issn.1008-0074.2012.04.02
- VernacularTitle:关于高血压患者血清HGF、sICAM-1水平的研究
- Author:
Yihong LI
;
Meihua JIN
;
Shuang YU
;
Bo YU
- Publication Type:Journal Article
- Keywords:
Intercellular adhesion molecule-1;
Hypertension;
Hepatocyte growth factor
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2012;21(4):345-349
- CountryChina
- Language:English
-
Abstract:
Objective: To study changes of serum levels of hepatocyte growth factor (HGF), soluble intercellular adhesion molecule-1 (sICAM-1) in patients with essential hypertension (EH) and their significance. Methods: A total of 59 EH patients were selected, including 20 cases with EH stage 1 (EH stage 1 group), 19 cases with EH stage 2 (EH stage 2 group) and 20 cases with EH stage 3 (EH stage 3 group). Another 30 healthy subjects were regard as normal control group. Double antibody enzyme-linked immunosorbent sandwich assay was used to measure concentrations of HGF and sICAM-1 in all groups, and then the results were compared and analyzed. Results: Compared with normal control group, there were significant increase in serum levels of HGF [(641.65±142.90) pg/ml vs. (998.15±241.38) pg/ml] and sICAM-1 [(161.70±32.36) ng/ml vs. (327.17±31.28) ng/ml] in EH patients (P<0.01 both), and it’s more significant as blood pressure increased (P<0.01). HGF concentration was positively correlated with sICAM-1 concentration (r=0.317, P<0.01). Conclusion: HGF and sICAM-1 may participate in pathogenesis of hypertension, indicating that HGF plays an important role in restore of impaired endothelial cells in hypertension.
- Full text:P020121009762838590913.doc
