Relationship between insulin sensitivity index and extent of coronary atherosclerosis in Uygur and Han nationality patients
10.3969/j.issn.1008-0074.2012.03
- VernacularTitle:维吾尔及汉族患者的胰岛素敏感指数与冠状动脉粥样硬化程度的关系
- Author:
Jie GAO
;
Yukai WANG
;
Liangzhen TU
- Publication Type:Journal Article
- Keywords:
Coronary arteriosclerosis;
Insulin;
Uygur nationality;
Han nationality
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2012;21(3):234-238
- CountryChina
- Language:English
-
Abstract:
Objective: To explore the relationship between insulin sensitivity index （ISI）and extent of coronary atherosclerosis in Uygur and Han nationality patients. Methods: A total of 125 patients with coronary heart disease were enrolled, including 59 Uygur nationality patients and 66 Han nationality patients. There were 42 cases with stable angina pectoris, 52 cases with unstable angina pectoris, 31 cases with old myocardial infarction, 53 cases with type 2 diabetes and 35 cases with hypertension. Relevant medical history of patients [age, body mass index (BMI) etc.] was collected and laboratory examination （blood lipid, fasting blood glucose, fasting insulin etc.）were performed, and extent of coronary atherosclerosis was evaluated by coronary angiography in all patients. ISI was calculated and its relationship with extent of coronary atherosclerosis was analyzed. Results: In both nationality patients, ISI was negatively correlated with extent of coronary atherosclerosis (Han nationality: r=-0.71, P=0.03, Uygur nationality: r=-0.52, P=0.04). ISI was negatively correlated with BMI, glycosylated hemoglobin (HbA1c) and low density lipoprotein –cholesterol (LDL-C) (r=-0.45, -0.68, -0.55, P<0.05 all) in Han nationality patients; ISI was positively correlated with high density lipoprotein–cholesterol (HDL-C, r=0.67, P<0.01), and negatively correlated with HbA1c, LDL and lipoprotein a (r=-0.47, -0.35, -0.42, P<0.05) in Uygur nationality patients. Conclusion: Insulin resistance participates and promotes formation and development of coronary atherosclerotic plaques. Controlling weight, blood glucose and LDL-C levels etc. can decrease insulin resistance and prevent occurrence and development of coronary heart disease.
- Full text:P020121009755252810033.doc
