Effect of salvia miltiorrhiza and ligustrazine on acute episode of chronic pulmonary heart disease
10.3969/j.issn.1008-0074.2011.0.
- VernacularTitle:丹参川芎嗪治疗慢性肺源性心脏病急性发作的疗效
- Author:
Limin CHEN
;
Zhenhui HUANG
- Publication Type:Journal Article
- Keywords:
Salvia miltiorrhiza;
Tetramethylpyrazine;
Pulmonary heart disease;
Hypertension, pulmonary
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2011;20(6):593-598
- CountryChina
- Language:English
-
Abstract:
Objective: To observe effect of salvia miltiorrhiza and ligustrazine injection on patients with acute episode of chronic pulmonary heart disease (CPHD) complicated pulmonary artery hypertension. Methods: A total of 40 CPHD patients with pulmonary artery hypertension were randomly divided into routine treatment group (n=20, received routine treatment) and observation group (n=20, received salvia miltiorrhiza and ligustrazine based on routine treatment). Another 20 healthy subjects were regard as healthy control group. The pulmonary artery pressure (PAP), partial pressure of oxygen in artery (PaO2) , left ventricular ejection fraction (LVEF) and levels of C-reactive protein (CRP) and endothelin-1 (ET-1) were examined and analyzed in all groups before and after treatment. Results: After treatment, compared with routine treatment group, there were significant increase in total effective rate (75% vs. 90%) and PaO2 [（83.87±14.53）mmHg vs.（92.95±13.54）mmHg], and significant decrease in mean PAP [mPAP, （55.43±9.65）mmHg vs.（45.52±8.89）mmHg], CRP [(6.37±2.12) mg/L vs. (3.29±0.84) mg/L] and ET-1 [(52.37±20.79) ng/L vs. (40.29±16.04) ng/L] in observation group (P<0.05~0.01). There was no significant difference in LVEF between the two groups after treatment (P>0.05). Conclusion: For patients with acute episode of chronic pulmonary heart disease complicated pulmonary artery hypertension salvia miltiorrhiza and ligustrazine injection can significantly improve clinical effects，right heart function, decrease mean pulmonary artery pressure, improve endothelial function and inhibit inflammatory reactions.
- Full text:P020120114767322039954.doc
