SYNTHESIS OF SARMENTOSIN
- VernacularTitle:垂盆草苷的合成
- Author:
Guohua CHU
;
Qiting ZHOU
;
Donglu BAI
- Publication Type:Journal Article
- Keywords:
sarmentosin;
glutamic-pyruvic transaminase(GPT);
total synthesis
- From:
Acta Pharmaceutica Sinica
1999;34(1):0-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: The synthesis of sarmentosin. METHODS: Condensation of butane-1,2,4-triol-1,2-acetonide(3) with α-D-glucopyranosyl bromide tetraacetate in the presence of Ag2O and molecular sieves gave the desired β-glucoside 4,which was transformed into sarmentosin via a reaction sequence of 7 steps. RESULTS: The overall yield is 5.8%. CONCLUSION: The first synthesis of sarmentosin(1),a potent natural GPT lowering agent,was achieved.
