Expression and significance of COX-2 protein and BCL-2 protein in distal transitional mucosa adjacent to rectal carcinoma
10.3969/j.issn.1009-9905.2011.01.018
- VernacularTitle:直肠癌远端移行黏膜COX-2及BCL-2蛋白的表达及意义
- Author:
Guodong PANG
;
Dongfeng ZHOU
;
Yang LI
;
Yibo LIANG
;
Lin CUI
- Publication Type:Journal Article
- Keywords:
Rectal carcinoma;
Transitional mucosa;
Cancer precursor event;
COX-2;
BCL-2
- From:
Chinese Journal of Current Advances in General Surgery
2011;14(1):55-58,70
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect the expressions of COX-2 protein and BCL-2 protein in transitional mucosa adjacent to rectal carcinoma,and determine whether the transitional mucosa was the cancer precursor event.Methods:Mucin histochemical method was employed to detect the distal mucosa 2 cm away from rectal tumor and the transitional mucosa was found in 54 cases of rectal carcinoma.Immunohistochemical method was used to investigate the expressions of BCL-2 and COX-2 protein in the specimen of rectal carcinoma mass,transitional mucosa and non-transitional mucosa,and 20 cases of normal rectal mucosa,and the points of the expressions of COX-2 protein and BCL-2 protein were counted.Results:35.19%(19/54)of distal mucosa were characterized as the transitional mucosa.The expressions of COX-2 and BCL-2 protein were detected in carcinoma mass and distal mucosa.Significant difference was observed in carcinoma mass and transitional mucosa(p<0.01).But there were no significant differences between the expressions of those in transitional mucosa and non-transitional mucosa(p>0.05),as well as transitional mucosa and normal mucosa(p>0.05).Conclusion:The performance of transitional mucosa was not the cancer precursor event,but the non-specificity reaction of carcinoma or inflammation.
