Correlation with expression of HMGB1 mRNA and clinicopathological features of endometrial carcinoma

VernacularTitle:高迁移率族蛋白1mRNA表达与子宫内膜癌临床病理特征的关系
Author: Rixue XIE ; Jiajie WU ; Ying XIE ; Meifang XIAO ; Cuixiang ZHOU
Publication Type:Journal Article
Keywords: High mobility group proteins/ME; Endometrial neoplasms/ME/PA
From: Journal of Chinese Physician 2011;13(1):41-43,48
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of HMGB1 mRNA in endometrial carcinoma and its correlation with clinicopathological features of endometrial carcinoma. Methods Semi-quantitative RT-PCR method was used to detect the expression level of HMGB1 gene in 56 cases of endometrial carcinoma and 20 cases of normal endometrium. Results The expression of HMGB1 mRNA in endometrial carcinoma (0. 3512 ± 0. 0985 ) was significantly higher than that in normal endometrium (0. 2208 ± 0. 0170 ).There was a significant difference in the two groups( P ＜0. 05 ). Grouping by clinicopathological features,the expression of HMGB 1 mRNA in endometrial carcinoma had a correlation with clinical-surgical stage ( P＜0. 05), metastasis of lymph nodes ( P ＜ 0. 05), and depth of myometrial invasion ( P ＜ 0. 05 ). Conclusion The high level of HMGB1 mRNA indicated that HMGB1 might play an essential role in the genesis, growth, invasion and metastasis of endometrial carcinoma.