Study of the expression of complement regulatory protein CD59 on CD4+ T cells and its relationship with apoptosis in HIV infected patients

VernacularTitle:CD59在艾滋病感染者CD4+T细胞表达及凋亡的影响
Author: Peize ZHANG ; Hui WANG ; Mingxia ZHANG ; Qiaoli PENG ; Xinchun CHEN ; Boping ZHOU ; Guiying LI ; Shuiteng LIU ; Yan LIU
Publication Type:Journal Article
Keywords: HIV-1,antigen; CD4+T cell; CD59; Apoptosis
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(7):865-867,后插3
CountryChina
Language:Chinese
Abstract: Objective To explore CD59 expression on CD4+T cells in HIV infected patients and its relationship with apoptosis.Methods 12 HIV infected patients and 10 healthy donors were performed in this study.The PBMC(peripheral blood monocyte)were collected and cell surface cytokine were stained,and then were evaluated with the BD FACSCanto flow cytometry.The expression of CD59 on T lymphocyte subsets were analyzed by FACSDiva software,and the apoptosis rate of CD59+CD4+T cells and CD59-CD4+T cells in every group was analyzed respectively,then the results were compared between groups.Results Compared with healthy donor,the expression of CD59 on T cells in HIV infected patients was significantly hisher(t=5.198,P＜0.01),and the apoptosis rate of CD59+CD4+T cells had significantly higher(t=5.968,P＜0.01).The apoptosis rate of CD59-CD4+T cells was no difference between two groups (t=0.1353,P=0.8577).Condnsion HIV infection increase CD59 expression on CD4+T cells,and CD59+CD4+T cells were prone to apoptosis.