Study on Mechanism of Reproduction Toxicity of to Estrogic Bisphenol-A Related to Environment
- VernacularTitle:环境雌激素双酚A的生殖毒理研究
- Author:
Maoxian DENG
;
Desheng WU
;
Li ZHAN
- Publication Type:Journal Article
- From:
Journal of Environment and Health
2001;18(3):134-136,150
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism of male reproductive toxicity of bisphenol-A.Methods The morphological characteristics of seminiferous tubule,vimentin filaments and p53 gene expression in sertoli's cells of adult SD rats orally exposed to 0.5% bisphenol-A were observed and analyzed by histo-chemical and immuno-histochemical methods.Results After 2-week-exposure to 0.50% bisphenol-A,the disattachment between sertoli's cell and spermatogonia,spermatogonia arranged in disorder and displacement of spermatogonia away from the basement membrance of seminiferous tubules as well as the flocculated chromatins of nuclei in sertoli's cells and spermatogonia were observed.Fourfold increase of p53 expression in nuclei of spermatogonia and leydig's cells and the collaps of vimentin filaments in sertoli's cells were also found.Conclusion The results suggested that the disattachment between sertoli's cells and spermatogonia,might be associated with the collaps of vimentin filaments in nuclei of sertoli's cells and the increase of p53 expres sion in nuclei of sertoli's cells and spermatogonia,which might be one of the important mechanisms of reproductive toxicity of bisphenol-A.The increase of p53 expression in nuclei of leydig's cells might predict the potential anti-androgenicity of bisphenol-A
