Subd iaphragmatic vagotomy reduce the responses of fever and c-Fos expression inrat PVN and NTS to LPS
- VernacularTitle:膈下迷走神经切断降低LPS所致大鼠发热及室旁核、孤束核c-Fos蛋白表达
- Author:
Xiuying LU
;
Guizhen YANG
- Publication Type:Journal Article
- From:
Chinese Journal of Immunology
2001;17(4):201-203，206
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the possibility that responses of fever and c- Fos expression in rat PVN and NTS to intraperitoneal administration of LPS are rnediated by vagal afferents. Methods: Rectal temperature was detected by digital temperature detecting instrument. c-Fos expressis was detected by immunohistochemistry staining.Results:The rectal temperature change value in vagotomy LPS gnoup was significantlydecreased compared with that in sham IPS group,and there was striking difference betwen them, p ＜0.05.It was increased significantlycompared with that in vagotomy NS group, P ＜ 0.05.The percentage of c-Fos positive neurons in rat PVN and NTS in vagotomy LPS group wassignificantly decreased compared with that in sham LPS group,and there were difference between them, p ＜0.01.Itwas stnkingly increased compared with that in vagotomy conrol group,respectively, P ＜0.01.Conclusion:The results indicate that vagus nerve is one of thepathways of peripheal LPS signal communicating to CNS.
