Mechanism of Helicobacter Pylori Inhibiting the Healing of Acetic Acid-Induced Gastric Ulcer in Rats
- VernacularTitle:幽门螺杆菌抑制大鼠乙酸胃溃疡愈合的机制
- Author:
Chengjun LI
;
Liding XIA
;
Li JIN
;
Guozhong WANG
- Publication Type:Journal Article
- Keywords:
Helicobacter Pylori(HP);
Ulcer;
Gastric acid secretion
- From:
Journal of Medical Research
2009;38(8):28-29,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mechanism of Helicobacter Pylori inhibiting the healing of acetic acid - induced gastric ulcer in rats. Methods Rats were infected with Helicobacter Pylori and the model of acetic acid gastric ulcer was replicated at 4 weeks after in-fection. Amount of G cell and D cell in mucosa of gastric antrum, quantity of gastric juice and pH were measured at the 3rd,Sth, 16th day after the model was replicated. Results When the group of Hp + acetic acid ulcer compared with the group of acetic acid ulcer, the number of G cell, quantity of gastric juice increased (P < 0.01), and the number of D cell and pH decreased (P < 0.01). Conclusion Helicobacter Pylori inhibits ulcer healing through increasing gastric acid secretion.
