The correlation between hepatitis B virus gene mutation at site 1896 in precore region and genotypes as well as liver function
10.3760/cma.j.issn.1673-4130.2009.07.024
- VernacularTitle:乙型肝炎病毒第1 896位点变异与基因分型同肝脏功能的相关性分析
- Author:
Zuofen CHEN
;
Yongping CAO
;
Peixue JIANG
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Gene mutation;
Genotype
- From:
International Journal of Laboratory Medicine
2009;30(7):680-681,684
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between hepatitis B virus gene mutation at site 1896 in precore region and genotypes as well as liver function parameters. Methods The fluorescent quantitative PCR and sequencing method were applied to measuring the relevant indicators in 50 patients with chronic hepatitis B. Results There was significant difference in ALT level between hepatitis B patients with site 1896 mutation and ones with wild-type; and HBV mutation at site 1896 in precore region was unrelated to the genotypes. Conclusion HBV mutation at site 1896 in precore region may be associated with continous viral invasion invasion into hepatocytes.
