Relationship between Body Mass Index and Serum Prostate-specific Antigen Levels in Prostate Cancer Patients

VernacularTitle:体重指数与前列腺特异性抗原关系研究
Author: Xiaolin WANG ; Mao MA
Publication Type:Journal Article
Keywords: Body mass index; Prostate-specific antigen; Prostate carcinoma
From: Chinese Journal of Clinical Oncology 2009;36(14):788-789,794
CountryChina
Language:Chinese
Abstract: Objective:The aim of this study was to examine whether PSA levels were affected by BMI and the influence of BMI on the clinical application of PSA.Methods:A total of 856 males who had routine health checkups between January 2006 and July 2007 in our hospital were recruited for this study.Those with a documented history of prostate carcinoma were excluded.Height,weight, and total PSA were measured.The BMl was calculated from measured height and weight [BMl=weight(kg)/height(m)2].Results:The serum PSA(ng/mL)levels were 2.97±0.15 in the normal weight group,2.53±0.12 in the overweight group,and 2.01±0.16 in the obese group(P＜0.05).A negative correlation was found between PSA and BMI(r=-0.130,P＜0.05)and weight(r=-0.142.P＜0.05).A positive correlation was found between PSA and age(r=0.306,P＜0.05).Con-clusion:BMl is associated with PSA.As BMI increases, serum PSA decreases.The current data suggest that such an influence should be considered in the clinical application of PSA.