An investigation for the effect of HLA-DRB1*07,13 allelic genes on the immune response to hepatitis B vaccination
- VernacularTitle:HLA-DRB1*07,13等位基因对乙肝疫苗免疫效果影响的研究
- Author:
Yinghua WEI
;
Jizhou WU
;
Jianlin WU
;
Guojian LI
;
Maowei CHEN
;
Yanhong YU
;
Shuang WU
;
Xingguang GONG
;
Yanli MENG
;
Yanqi YU
- Publication Type:Journal Article
- Keywords:
Hepatitis B vaccine;
HLA-DRB1*07,13;
Immune response
- From:
Chinese Journal of Immunology
2009;25(11):996-998,1002
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of HLA-DRB1*07,13 allelic genes on the immune response to hepatitis B vaccination.Methods:896 healthy college students of Han nationality from Guangxi province,who had received standard courses of vaccination with recombinant hepatitis B virus vaccine,were tested the level of anti-HBs with ELISA method at the sixth month after their last vaccination.The non- or hypo-responders were selected to receive another 20 μg doses of recombinant vaccine and were examined anti-HBs once more four weeks later.99 non- or hypo-responders and 136 medium or hyper-responders were selected for the study subjects.HLA-DRB1*07,13 allelic genes of the subjects were detected by polymerase chain reaction using sequence specific primer (PCR-SSP) method.Results:The frequencies of HLA-DRB1*07 gene in the non- or hypo-responders group were significantly higher than that in the medium or hyper-responder group (16.16% vs 4.41%,P＜0.05). No significant difference of HLA-DRB1*13 gene between the two groups (1.01% vs 3.68%,P=0.389).Conclusion:There is a close relationship between the expression of HLA-DRB1*07 gene and the non- or hypo-response to HB vaccine;No relationship between HLA-DRB1*13 gene expression and the response to HB vaccine is found.
