The Correlation between MR Perfusion Imaging and Pathology in Rabbit VX2 Liver Cancer before and after TACE
10.3969/j.issn.1000-8179.2009.23.014
- VernacularTitle:免VX2肝癌TACE前后MRDWI与病理对照研究
- Author:
Yi FAN
;
Jinghua LIU
;
Tianjun GAO
;
Bing LIANG
;
Zhehui LIU
;
Yong LI
;
Mingwu LOU
- Publication Type:Journal Article
- Keywords:
VX2 tumor model;
Liver cancer;
Chemoembolization;
Pathology
- From:
Chinese Journal of Clinical Oncology
2009;36(23):1365-1366,1369
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the correlation between MR perfusion imaging and pathology after transcatheter arterial chemoembolization (TACE) using VX2 liver cancer model and to provide a theoretical basis to evaluate the curative effect of TACE. Methods; Fifteen New Zealand white rabbits (weight: 2.5-3.0kg) were randomly divided into three groups, with 5 in each group (group 1, pre-TACE; group2, 3 days after TACE; group 3,1 week after TACE). The rabbit VX2 hepatic carcinoma models were presented in all rabbits. All of the three groups received TACE at three weeks after the tumor was implanted. The MR perfusion imaging was performed before chemoembolization, at 3 days and 1 week after chemoembolization respectively for group 1, 2 and 3. Each animal was then sacrificed for pathology observation after MR examination. Results: The lesions assessed before TACE were hyperintense compared with the surrounding liver parenchyma on DWI images. The volume of neoplastic cells became large. Nucleus was hypertrophic with different size and shape. Phase of nucleous mitosis showed in many cells and necrosis was hardly seen. No obvious difference was found between the peripheral area and the core area. At 3 days after TACE, the heterogeneous hypo-intense was observed on DWI images. Many nuclear fragmentation and caryolysis appeared on pathology. Neoplasm necrosis was seen. At 1 week after TACE, the heterogeneous hypo-intense areas became larger. Light microscopy showed incomplete necrosis. There were increased karyopycnosis and nuclear fragmentation. Conclusion: MR perfusion imaging of VX2 liver cancer corresponds well with pathology and can reflect the outcome of liver cancer after TACE.
