Effect of Rongban Tongmai Granules on thrombosis and blood viscosity of in vitro rat model of stasis
- VernacularTitle:融斑通脉颗粒对血淤模型大鼠体外血栓形成及血液黏度的影响
- Author:
Zhijian YUAN
;
Wenjuan HE
;
Lanfang ZHANG
;
Rui DENG
- Publication Type:Journal Article
- Keywords:
Rongban Tongmai Granules;
thrombosis;
blood viscosity
- From:
Chinese Journal of Biochemical Pharmaceutics
2009;30(6):412-414,418
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To observe the effect of Rongban Tongmai Granules on thrombosis and blood viscosity of in vitro rat model of blood stasis, and to study the activating blood circulation effect of the drug.Methods To observe the effect of the Rongban Tongmai Granules on thrombosis and blood viscosity of in vitro rat model of stasis, subcutaneous inject rat with epinephrine hydrochloride, and then copy "blood stasis" model by ice water stimulation in rats.Results According to a continuous 7 days′intragastric administration of Rongban Tongmai Granules, thrombus length of blood stasis model rats in vitro reduced significantly (P<0.05-0.01),wet and dry weight of thrombus reduced significantly (P<0.05), the shear rate of the whole blood viscosity under 100 S~(-1), 30 S~(-1), 5 S~(-1) decreased significantly as well (P<0.05-0.01), and the shear rate of whole blood viscosity had decreasing tendency under 200 S~(-1).Conclusion Rongban Tongmai Granules can inhibit thrombosis and lower blood viscosity.
