Exclusive Gene Mapping in an Congenital Hyperthyroidism Family
10.3870/j.issn.1672-0741.2010.01.031
- VernacularTitle:一个先天性甲状腺功能亢进症家系的排除性定位分析
- Author:
Shouyan ZHANG
;
Xu WANG
;
Junguo YANG
;
Tucheng SU
;
Mu LIU
;
Qing WANG
- Publication Type:Journal Article
- Keywords:
congenital hyperthyroidism;
autosomal dominant;
TSHR;
THRB;
microsatellite;
linkage analysis
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2010;39(1):124-126,132
- CountryChina
- Language:Chinese
-
Abstract:
Objective Gene linkage would be processed in order to make sure if an autosomal dominant congenital hyperthyroidism family has genetic linking relationship with the known hyperthyroidism disease genes,TSHR or THRB.Methods Microsatellite marked gene linkage was done with the use of three microsatellite markers,D14S74,D3S2338 and D3S1266,whose chromosomal locations were very close to TSHR or THRB gene,and the results were analyzed by Genemapper 3.5 Software.Results LOD scores of the three markers were all less than 1,revealing that there were no linking relationships between TSHR or THRB gene and this hyperthyroidism family,further reflecting this family might have a new disease gene other than TSHR and THRB.Conclusion There might be new disease genes responsible for autosomal dominant congenital hyperthyroidism.
