Expressions of LKN-1,CCR1 and CCR3 in Placentas of Pregnant Women with Hypertensive Disorder
- VernacularTitle:趋化因子LKN-1及其受体CCR1和CCR3在妊娠期高血压疾病中的表达
- Author:
Nannan LI
;
Yanxia LIU
;
Xin WANG
- Publication Type:Journal Article
- Keywords:
Hypertensive disorder complicating pregnancy;
Leukotactin-1;
CC receptor 1;
CC receptor 3
- From:
Journal of Practical Obstetrics and Gynecology
2010;26(1):27-30,后插1
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the role of Leukotactin-1(LKN-1),CC receptor 1(CCR1)and CC receptor 3(CCR3)in the pathogenesis of hypertensive disorder complicating pregnancy(HDCP),the expressions of these factors in placentas were measured.Methods:The levels of LKN-1,CCR1 and CCR3 in placentas were measured from 32 patients with HDCP(study group)and 32 normal pregnant women(control group)by western blot(WB).The localization of these factorsin placentas were detected by immunohistochemistry(IHC).Results:LKN-1 protein expression was negative in placentas from the two groups by WB and IHC,while both CCR1 and CCR3 in the HDCP group were significantly lower than those in the control group(CCR1 0.66±0.06 vs 0.88±0.03.CCR3 0.17±0.01 vs 0.27±0.01,P<0.01).CCR1 was localized in vascular endothelial cells and stroma cells in both groups,but rare in the trophoblast layer.CCR3 was localized in vascular endothelial cells and trophoblast cells in both groups.Conclusions:There is no LKN-1expression in placentas from the two groups.Down regulation of CCR1 and CCR3 may associate with the pathogenesis of HDCP.
