Treatment with 1Hz repetitive transcranial magnetive stimulation in auditory hallucination of schizophrenia: A double blind, randomized controlled trial

VernacularTitle:低频重复经颅磁刺激治疗精神分裂症顽固性幻听的随机双盲对照研究
Author: Yanping REN ; Dongfeng ZHOU ; Zhuoji CAI ; Qing HUANG ; Ling LU ; Qi CHEN
Publication Type:Journal Article
Keywords: schizophrenia; auditory hallucination; repetitive transcranial magnetic stimulation (rTMS); randomized controlled trial
From: Chinese Mental Health Journal 2010;24(3):195-197,205
CountryChina
Language:Chinese
Abstract: Objective: To examine the therapeutic effects of dual dorsolateral prefrontal repetitive transcranial magnetic stimulation (rTMS) on auditory hallucinations experienced by schizophrenic patients. Methods: A double-blind randomized controlled study was conducted. Totally 25 schizophrenic patients met DSM-Ⅳ criteria for schizophrenia and had anditory hallucination with stable antipsychotic drugs treatment were recruited. Subjects were grouped into active treatment subgroup and sham subgroup randomly. Measurements including the Positive and Negative Symptom Scale (PANSS) for clinical symptom and the Treatment Emergent Symptom Scale (TESS) for side-effects were evaluated Results: Totally 25 subjects completed the trial. The treatment efficiency of active treatment group was higher than that of sham group (75% vs. 31%) .No overt side effects of rTMS were observed. Conclusion: It is effective for rTMS to treat schizophrenia with auditory hallucination at 1Hz. rTMS may be a new selection of schizophrenia treatment.