Stereological Study on Syncytial Cell of Human Placenta in Early-onset Severe Preeclampsia
- VernacularTitle:早发型重度子痫前期胎盘组织超微结构的体视学研究
- Author:
Yuqin HU
;
Yuanli HE
;
Shilei PAN
- Publication Type:Journal Article
- Keywords:
Early-onset;
Preeclampsia;
Placenta;
Stereology
- From:
Journal of Practical Obstetrics and Gynecology
2010;26(3):219-221,前插1
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The characteristics and changes of the three-dimensional micro structure of human placenta in Early-onset severe preeclampsia (EOSP) were quantified, and the relationship of morphologic features and the poor fetal prognosis was explored. Methods:10 patients were recruited in EOSP group, 10 normal blood pressure premature pregnancy were as control group. Ultrathin sections were observed by elec-tron microscope. The Vv,Sv,Nv of plancenta were measured by stereology method. These parameters were compared between the two groups. Results:①In EOSP group, the miorovillus at the bottom of syncytial was sparse and swollen. The mitochondria and endoplasmic reticulum were swollen and dilated. The deposition of lipid granules were increased.②The Vv, Sv of mitochondrial and endoplasmic reticulum in EOSP group were significant augmented than control groups( P<0.01 ). There was no significant difference of Nv in mitochon-drion and endoplasmic reticulum between two groups ( P >0.05). ③The Vv,Sv, Nv of microvilli in EOSP group were smaller than those in control group ( P < 0.01 ). Conclusions. In EOSP, the microstructure of placenta is impaired, thus the synthesis and transportation function of placenta were affected, so fetus could be injured subsequently.
