Expression of Histamine H4 Receptor in Allergic Rhinitis and Its Clinical Significance
- VernacularTitle:组胺H4受体在变应性鼻炎中的表达及临床意义
- Author:
Hua PENG
;
Hangui LU
;
Hongyan JIANG
;
Zhibin LIN
;
Yanqiu CHEN
;
Dehua CHEN
;
Tianying LI
- Publication Type:Journal Article
- Keywords:
histamine H4 receptor;
allergic rhinitis;
interleukin 4;
intedeukin 12
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2010;31(2):195-198,206
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]This study was designed to discover the expression of histamine H4 receptor in allergic rhinitis(AR)and its clinical significance.[Methods]Seventy-three patients with allergic rhinitis and 30 volunteers were recruited in our study.Western blot and Real-time fluorescent quantification PCR were used to detect the protein and mRNA expression of H4R on peripheral blood monocytes(PBMC).To analyze the relationship between the H4R and allergic rhinitis,the level of serum interleukin 4(IL-4)and interleukin 12(IL-12)were determined by enzyme linked immunosorbnent assay(ELISA)in the AR group.[Results]The protein and mRNA expression of H4R in the AR group were significantly higher than that in the NAR group.Person correlation analysis revealed that H4R was positively correlated with IL-4(r=0.71,P＜0.01)and negatively correlated with IL-12(r=-0.50,P＜0.01).The expression of H4R also had positive relationship with IL-4/IL-12 ratio(r=0.75,P＜0.01).[Conclusion]These results indicate that histamine H4 receptor is closely related with allergic rhinitis and is important in the pathogenesis of AR.The elevated expression of H4R in AR patients' PBMC may be closely correlated with Th1/Th2 balance.
