Study the significance of blood VEGF,PAPP-A,D-D and urinary NAG/Cr ratio in patients with PIH

VernacularTitle:探讨血VEGF、PAPP-A、D-D和尿NAG/Cr对妊娠高血压综合征的临床意义
Author: Qiurong PAN
Publication Type:Journal Article
Keywords: pregnancy complications; hypertension; endothelial growth factors; pregnancy associated alpha plasma protein; Laboratory Techniques and Procedurespregnant induced hypertension syndrome(PIH); VEGF; PAPP-A; D-dimers
From: International Journal of Laboratory Medicine 2010;31(6):561-562,564
CountryChina
Language:Chinese
Abstract: Objective To study the clinical significance of changes of blood contents of vascular endothelial growth factors (VEGF).Pregnancy-associated plasma protein-A(PAPP-A),D-dimers(D-D)and Urinary N-acetyl-β-D-glucosaminidase/Creatinine (NAG/Cr)Ratio in patients with Pregnancy Induced Hypertension syndrome(PIH).Methods Serum VEGF and PAPP-A(with ELISA),plasma D-dimers(with biochemistry)and NAG/Cr(with velocity)contents were measured in 92 pregnant women with PIH and 35 controls.Results The serum VEGF contents in patients with PIH were significantly lower than those in controls(P<0.01)while PAPP-A,D-dimers and NAG/Cr contents were significantly higher(P<0.01).Those changes were especially marked in patients with advanced diseases.Conclusion Changes of blood contents of VEGF,PAPP-A D-dimers and Urinary NAG/Cr Ratio were closely related with the disease process of PIH.Determination of these changes was of clinical diagnostic as well as prognostic value.