The effect of melatonin on hepatic tissue of autoimmune hepatitis
- VernacularTitle:褪黑素对自身免疫性肝炎肝组织病变的影响
- Author:
Yong MA
;
Tilong DING
;
Fuhua YUAN
;
Zhixue XIA
- Publication Type:Journal Article
- Keywords:
Melatonin;
Hepatitis,antoimmune diseases;
Elastic fibers;
Viscose;
Vascular endothelial growth factors
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(5):713-715,插1
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of melatonin (MT) on hepatic tissue of autoimmune hepatitis (AIH). Methods AIH model rats were divided randomly as model group, MT group and pig hepacyte growth factor (pHGF) group, to observe the pathological changes of hepatic tissue of the three groups. Results Hepatic tissue inflammation and accrementition graded of elastic fibers, reticular fibre, collagenous fibrils of MT group [(0.97±0.16),(1.09±0.17),(1.31±0.17)] were much lighter than model group [(1.55±0.18),(2.00±0.14),(3.00±0.14)](all P<0.01). The expression of VEGF was weaker in MT group than in pHGF group. There was no distinct difference between MT group and pHGF group. Conclusion MT can obviously improve the pathological changes of hepatic tissue of rats with AIH.
