Effect of carvedilol on the stability of plasma catecholamine in patients with myocardial infarction
- VernacularTitle:卡维地洛对心肌梗死患者血清儿茶酚胺水平的影响
- Author:
Huiyun ZHOU
;
Shengxi ZHEN
;
Ping SHU
;
Jinsen HU
;
Shaowei JIA
;
Xiancui FEI
;
Xiaoping YU
- Publication Type:Journal Article
- Keywords:
Sympathetie nervous system;
My ocardial infaretion;
Epinephrine;
Norepinephrine
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(10):1660-1662,插3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of carvedilol on the stability of plasma catecholamine in patients with post-acute myocardial infarction during consecutive periods. Methods Thirty-slx patients selected with acute myocardial infarction were randomized to experimental group treated with the nonselective beta-blocker earvedilol( n=18) and control group treated with the selective beta-blocker metoprolol(=18) for 12-months follow-up. In the two groups,the concentrations of plasma norepinephrine and epinephrine were measured before the treatment and after 2 months,4 months,6 months,8 mouths,10 months and 12 months and new cardiac events were supervised. Results After the treatment, in each point of periods, experimental group showed lower concentrations of plasma norepinephrine and epinephrine statistically than control group(P<0.05) ,and a stable dynamic change during 12 months of treat-ment( P>0.05 ) ;the occurrence rate of new cardiac events was lower significantly in experimental group than in con-trol group(P<0.05). Conclusion Carvedilol can decrease the spillover of sympathetic nerve, control more stably cardiac sympathetic nerve activity and then decrease more sharply the occurrence rate of new cardiac events in pa-tients with acute myocardial infarction than metoprolol.
