Relationship Between Obesity and N-Terminal Brain Natriuretic Peptide Level as a Prognostic Value After Acute Myocardial Infarction.
10.4070/kcj.2010.40.11.558
- Author:
Seon Gyu CHOI
1
;
Myung Ho JEONG
;
Youngkeun AHN
;
Jeong Gwan CHO
;
Jung Chaee KANG
;
Shung Chull CHAE
;
Seung Ho HUR
;
Taek Jong HONG
;
Young Jo KIM
;
In Whan SEONG
;
Jei Keon CHAE
;
Jay Young RHEW
;
In Ho CHAE
;
Myeong Chan CHO
;
Jang Ho BAE
;
Seung Woon RHA
;
Chong Jin KIM
;
Donghoon CHOI
;
Yang Soo JANG
;
Junghan YOON
;
Wook Sung CHUNG
;
Ki Bae SEUNG
;
Seung Jung PARK
Author Information
1. Department of Internal Medicine, Yeosu Chonnam Hospital, Yeosu, Korea.
- Publication Type:Original Article
- Keywords:
Brain natriuretic peptide;
Obesity;
Myocardial infarction
- MeSH:
Acute Coronary Syndrome;
Body Mass Index;
Brain;
Female;
Follow-Up Studies;
Heart Failure;
Humans;
Korea;
Male;
Myocardial Infarction;
Natriuretic Peptide, Brain;
Obesity;
Overweight;
Peptide Fragments;
Risk Factors
- From:Korean Circulation Journal
2010;40(11):558-564
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: Recently, the prognostic value of N-terminal brain natriuretic peptide (NT-proBNP) in acute coronary syndrome has been demonstrated in many studies. However, NT-proBNP levels are influenced by various factors such as sex, age, renal function, heart failure severity, and obesity. NT-proBNP concentrations tend to decrease with higher body mass index (BMI). The aim of this study was to examine the influence of obesity on NT-proBNP as a predictive prognostic factor in acute myocardial infarction (AMI) patients. SUBJECTS AND METHODS: Using data from the Korea Acute Myocardial Infarction Registry (January 2005 to September 2008), 2,736 AMI patients were included in this study. These patients were divided into men (n=1,972, 70%) and women (n=764, 30%), and were grouped according to their BMIs. Major adverse cardiac events (MACE) during 1 year clinical follow-up were evaluated. RESULTS: NT-proBNP was significantly higher in lower BMI (p<0.001). Mean NT-proBNP levels of each obesity group were 2,393+/-4,022 pg/mL in the lean group (n=875), 1,506+/-3,074 pg/mL in the overweight group (n=724) and 1,100+/-1,137 pg/mL in the obese group (n=1,137) (p<0.01). NT-proBNP was an independent prognostic factor of AMI in obese patients by multivariative analysis of independent risk factors of MACE (p=0.01). CONCLUSION: NT-proBNP is lower in obese AMI patients than in non-obese AMI patients, but NT-proBNP is still of independent prognostic value in obese AMI patients.
