Polyvinyl alcohol-chitosan-collagen as scaffolds for tissue engineering
10.3760/cma.j.issn.1673-4181.2009.01.005
- VernacularTitle:聚乙烯醇-壳聚糖-胶原组织工程支架的研究
- Author:
Xiaohui MO
;
Qinhua LI
;
Huifeng ZHANG
- Publication Type:Journal Article
- Keywords:
Polyvinyl alcohol;
Chitosan;
Collagen;
Tissue engineering;
Scaffold
- From:
International Journal of Biomedical Engineering
2009;32(1):18-21,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To fabricate a novel polyvinyl alcohol (PVA)-chitosan(Cs)-collagen (Col) composite material and to confirm the feasibility of its application as a scaffold in tissue engineering.Methods PVA was blended with chitosan and collagen.The water content,swelling ratio,and tensile strength of the scaffolds were tested.SEM was used to observe the histological modality of the cross section.Results Scaffolds which al'e composite with different molecular weight and different amount of Cs and Collagen ale made,with water content ranging from 60.15% to 72.50% and swelling ratio being from 185.33% to 317.57%.The tensile strength of the composite material is 5.70MPa.The inner modality and structure of the scaffolds varied as the proportion of the chemical components changed.Conclusion PVA-Cs-Col scaffolds have high water content and proper swelling ratio and ale rich in porous structure.When the blending proportion is Cs:PVA:COI=30:15:0.20,the scaffold performs best,which shows to be a suitable structure for tissue engineering scaffold.
