Investigation of correlation between systemic lupus erythematosus and human cytomegalovirus infection
10.3760/cma.j.issn.1007-7480.2009.03.003
- VernacularTitle:人巨细胞病毒感染与系统性红斑狼疮的相关性研究
- Author:
Yingwei LI
;
Jianhua XU
;
Li LIAN
;
Huan CUI
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Human cytomegalovims;
Polymerase chain reaction;
Indirect immunoffuorescence
- From:
Chinese Journal of Rheumatology
2009;13(3):152-155,插1
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between systemic lupus erythematosus (SLE) and human cytomegalovirus (HCMV) infection.Methods HCMV was isolated from the peripheral blood leucocytes (PBL) of 63 patients with SLE.Indirect immunofluorescence (IIF) was performed to investigate HCMV pp65 antigen and polymerase chain reaction (PCH) was performed to investigate the expression of HCMV UL54 DNA in cell cultures.The clinical and Iaboratory parameters were also assessed.Results The rate of HCMV infection in SLF patients was higher than that in the healthy controls and SLE patients.It was higher in the active phase than in the inactive phase.The total amount of urine protein in 24 houm collection,ESR,SLEDA1,preyalence of arthritis and some autoantibodies were considerably higher in patients with positive HCMV infection than those with negative HCMV infection.Conclusion The HCMV infection rate in SLE patients is higher than healthy controls.HC:MV infection may contribute to the disease flare in some SLE pahents.
