Influence of jiaweibugan decoction on the expression of JNK mitogen-activated protein kinase in sciatic nerve of experimental diabetic rats
- VernacularTitle:加味补肝汤对糖尿病大鼠坐骨神经中JNK丝裂原活化蛋白激酶表达的影响
- Author:
Juan HUANG
;
Zeqi CHEN
;
Lili XIONG
;
Jieyu LI
- Publication Type:Journal Article
- Keywords:
Reforeing liver & kidney;
Decoctions;
Diabetic neuropathies/ZD;
Sciatic nerve;
p38 mitogen-activated protein kinase
- From:
Journal of Chinese Physician
2009;11(2):156-159,169
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of jiaweibugan decoction on the expression of p-JNK mitogen-activated protein kinase in sciatic nerve of experimental diabetic rats and explore the preventive and therapeutic effects of Jiaweibugan decoction on peripheral neuropa-thy in experimental diabetic rats. Methods The diabetic rat model was established by streptozotocin (STZ). The rats were killed on the 4th or 8th week from the beginning of treatment, and the expression of p-JNK mitogen-activated protein kinase in sciatic nerve was detected by immunohistochemistry. Serum SOD was determined by xanthine oxidasemethod. Results The immunohistochemistry results showed that the expression of p-iNK in the model group on the 4th or 8th week was higher than that in normal control group (P<0.05) , while p-JNK in jiaweibugan decoction group was markedly lower than that in model rats(P<0.05). The results showed that SOD in the model group on the 4th or 8th week was lower than that in the normal control group (P<0.05) , while SOD in jiaweibugan decoction group was markedly high-er than that in model rats(P<0.05). Conclusion Jiaweibugan decoction has a preventive and therapeutic effect on peripheral neuropathy in experimental diabetic rats.
