Pancreatic β-cell and insulin secretion——plasticity and decompensation?
10.3760/cma.j.issn.1000-6699.2009.01.047
- VernacularTitle:胰岛β细胞与胰岛素分泌——可塑性与失代偿?
- Author:
Changyu PAN
- Publication Type:Journal Article
- Keywords:
β-cell;
Insulin secretion;
Diabetes mellitus,type 2
- From:
Chinese Journal of Endocrinology and Metabolism
2009;25(2):-
- CountryChina
- Language:Chinese
-
Abstract:
Normal β-cell is responsible for the glucose-induced insulin secretion.The β-cell plasticity plays an important role in glucose homeostasis,the mechanisms of which involve cell proliferation and apoptosis.β- cell dysfunction is a key factor in the impaired glncose metabolism,especially in the demand of increased insulin secretion to compensate insulin resistance.Impaired insulin secretion occurs in the early stages of type 2 diabetes and is characterized by the abnormal early phase secretion.
