The clinical value of prostate specific antigen for diagnosis of prostate cancer
10.3760/cma.j.issn.1008-6706.2009.07.039
- VernacularTitle:前列腺特异性抗原检测诊断前列腺癌的价值
- Author:
Guangda HE
;
Guanghua PENG
;
Huiqin ZHANG
;
Bilin YANG
;
Xihuan ZHOU
;
Jiali LU
;
Shan LIN
;
Yunfeng WENG
- Publication Type:Journal Article
- Keywords:
Prostate,neoplasm;
Prostate-specific antige
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(7):1212-1213,1346
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the relationship between free/total prostate specific antigen (f/t PSA), PSA density(PSAD) and prostate cancer(PCa), to explore healthy middle and old-aged,the patients with BPH, the scope of reference value of PSA,frce PSA(fPSA), f/t PSA and PSAD in patients serum with PCa. Methods To de-tect 307 cases of healthy gerontism male,236 of BHP and 41 of PSA and fPSA in patients with PCa,to calcuLate f/t PSA and PSAD, to investigate the dependability between PSA ,I"PSA ,f/t PSA ,P SAD and healthy male, the patients ofBHP,the PCa ,to determine the scope of reference value PSA,fPSA,f/t PSA and PSAD fitting for Chinese. Results PSA and fPSA in patients with PCa are obviously higher than normal control(P <0.01). f/t PSA is obviously lower than the BPH and normal control(P < 0.01). When PSA is 9.25 and f/t PSA is 20%, there are better value of clini-cal diagnosis,when PSAD is 0.18 (AUC = 0.635), we can get best aceuration of diagnosis. Conclusions f/t PSA and PSAD are better than PSA in clinical diagnosis. When PSA is more than 9.25,f/t PSA is less than 20% or PSAD is more than 0.18 is significance for diagnosis. The normal reference value of PSA less than 9.25,f/t PSA more than 20%, PSAD less than 0.18 is fit for Chinese.
