The Research Status of Anti-tumor Effects of Artemisinin and its Derivatives
10.3760/cma.j.issn.1673-4246.2009.02.045
- VernacularTitle:青蒿素及其衍生物抗肿瘤作用的研究现状
- Author:
Gaohua NIU
;
Hua WU
- Publication Type:Journal Article
- Keywords:
Artemisinin;
Anti-tumor
- From:
International Journal of Traditional Chinese Medicine
2009;31(2):174-175,184
- CountryChina
- Language:Chinese
-
Abstract:
Artemisinin is a traditional anti-malarial drug. In recent years, many researches indicated that artemisinin and its derivatives have obvious anti-tumor effects. Its mechanisms of anti-tumor lies in cytotoxicity, direct destruction of tumor cells due to oxidative stress reaction, inducing apoptosis, inhibiting of tumor cell proliferation, restraining tumor angiogenesis and performing immunological regulation. Compared with the traditional anti-cancer drugs, artemisinin can selectively inhibit tumor cells and manifestating no cross-resistance with traditional chemotherapeutic agents. Besides it can reverse the phenomenon of multi-drug resistant of tumor cells. Therefore, artemisinin, as an new type of anti-cancer drug, will be applied to a wide range of clinical practice.
