Influence of Xin-ke-shu Capsule on NO and ET in Patients with Coronary Artery Disease and Type 2 Diabetes Mellitus
10.3760/cma.j.issn.1673-4246.2009.04.006
- VernacularTitle:心可舒对冠心病合并2型糖尿病患者 NO、ET的影响
- Author:
Junrong DING
;
Huaqiang XU
;
Yiwei ZHOU
;
Jing REN
- Publication Type:Journal Article
- Keywords:
Xin-ke-shu Capsule;
Coronary artery disease combined with type 2 diabetes mellitus;
Nitric oxide;
Endothelin
- From:
International Journal of Traditional Chinese Medicine
2009;31(4):301,304-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influence of Xin-ke-shu Capsule (XKSC) on NO and ET in patients with coronary artery disease(CAD) combined with type 2 diabetes mellitus(T2DM), and to investigate its mechanism of treatment. Methods 80 patients with CAD combined with T2DM were randomly recruited into two groups: 40 patients in the treatment group were treated by conventional therapy plus XKSC, and the 40 in the control group treated by conventional therapy exclusively. The plasma level of NO and ET was observed before and after the three-month therapeutic course. Results The plasma level of ET in the treatment group significantly decreased after the treatmaent and was lower than that in the control group(P<0.01), but NO in the treatment group elevated significantly and was higher than that in the control group (P<0.01). Conclusion Xin-ke-shu Capsule displays its effect on protecting vascular endothelia by elevating the level of NO and decreasing the plasma level of ET.
