Rheumatoid-like deformities in Parkinson disease: one case report and review of literature
10.3760/cma.j.issn.1007-7480.2009.04.012
- VernacularTitle:帕金森病合并类风湿样关节畸形一例并文献复习
- Author:
Xiaoming SHU
;
Mengjun ZHAO
;
Li MA
;
Xin LU
;
Yao XIE
;
Hua ZHAO
;
Guochun WANG
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
Joint deformities,acquired;
Arthritis,rheumatoid
- From:
Chinese Journal of Rheumatology
2009;13(4):255-258,后插1
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical, laboratory, X-ray and the pathological features of Parkinson disease patients with rheumatoid-like deformities. Methods One patient was described and the relevant English literature in recent 50 years were reviewed. Results Rheumatoid-like deformities in Parkinson disease was mostly observed in women. The ratio between male and female was about 1:5.6. Joint deformities occurred after 7.6 years of Parkinson's disease in average. The manifestations of joints included the flexion of the metacarpophalangeal (MCP) joints, hyperextension of the proximal interphalangeal (PIP) joints, flexion of the distal interphalangeal (DIP) joints, and ulnar deviation of wrists and bilateral feet hallux valgus. Whole-blood analysis, biochemistry profile, erythrocyte sedimentation rate, C -reactive protein were all in normal range. Rheumatoid factor and ANA, anti-ENA profile, AKA, anti-cyclic citrullinated peptide (anti-CCP) antibody and antiperinuclear factor (APF) were all negative. Periarticular erosion was not observed in plaint X -ray films. Synovial pathology showed non -specific infla -mmation without classical syno vial membrane proliferation and pannus formation. NSAIDs and DMARDs were uneffective, but on the contrary, anti -parkinson' s disease therapy could relieve joints symptoms. Conclusion Parkinson disease can be accompanied with rheumatoid-like deformities which may be misdiagnosed as RA and should be differentiated from RA by laboratory, radiographs and synovium pathology examination.
