Relationship between cyclooxygenase-2 and vascular endothelial growth factor with liver sinusoidal capillarization of chronic hepatitis B

VernacularTitle:环氧合酶-2和血管内皮细胞生长因子与慢性乙型肝炎肝窦毛细血管化的关系
Author: Li YU ; Jianming XU ; Jiachun YAN ; Yong MA ; Changjiang XU
Publication Type:Journal Article
Keywords: Epoxide hydrolases; Angiogenesis inhibitors; Liver sinusoidal capillarization; Hepatitis B,chronic
From: Chinese Journal of Primary Medicine and Pharmacy 2009;16(9):1556-1557,插2
CountryChina
Language:Chinese
Abstract: Objective To study the relationship between expression of cyclooxygenase-2 (COX-2) and vas-culax endothelial growth factor (VEGF) with liver sinusnidal capillarization (LSC) of chronic hepatitis B (CHB). Methods We studied liver biopsies from 200 patients with CHB COX-2 ,VEGF immunohistochemical stain were ob-served to accomplish relationship between expression of COX-2,VEGF and LSC. Results LSC occupy above 80% in the group. There were manifestation in mild-LSC (focal) , middle-LSC (sheet-shape) and severe-LSC (widespread). Electron microscope shown the laceration in the endothelium of sinuses and formation of basal lamina and budding for-mation lumen of blood vessel and fat-storing cell convert myofibroblast. Expression of COX-2, VEGF, Co-Ⅳ and retic-ulum, collagen and elastic fibers with mild or severe in LSC is manifest locking relate. Conclusion Increased ex-pression of COX-2 ,VEGF in liver tissue of CHB may facilitate LSC and hepatic fibrosis.