Biocompatibility of porous drug implant scaffolds based on 3D printing technology
10.3760/cma.j.issn.1673-4181.2009.05.002
- VernacularTitle:基于三维打印技术的多药控释型载药人工骨生物学评价
- Author:
Weigang WU
;
Qixin ZHENG
;
Xiaodong GUO
- Publication Type:Journal Article
- Keywords:
Drug implant;
Three dimensional printing;
Drug delivery system;
Biomaterial;
Tissue engineering;
Biocompatibility
- From:
International Journal of Biomedical Engineering
2009;32(5):262-266,后插1
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the biocompatibility of porous drug implant scaffolds prepared by 3D printing technique. Methods Porous drug implant scaffolds were fabricated by 3D printing technique, and a series of tests were carried out to validate the biocompatibility, including acute systemic toxicity, hot source test, local irritation reaction, micronucleus test, muscle implant test and so on. Results The porous drug implant scaffolds showed no acute systemic toxicity, no pyrogenetic effect, no local erythema and edema in local irritation re-action, hemolysis rate of 0.29%, no cellular genetoxic. No local tissue denaturation, necrosis and exclusion were found in intramuscular implant test. Conclusion With good biocompatibility, the porous drug implant scaffold fabricated by 3D printing technique can meet the clinical requirement for biomaterial.
