Therapeutic efficacy of transcather arterial chemoembolization for hepatic carcinoma and its influence on hepatic function: a retrospective study of 92 patients
10.3760/cma.j.issn.1673-4203.2010.01.010
- VernacularTitle:肝动脉栓塞化疗治疗原发性肝癌疗效观察(附92例报告)
- Author:
Yangxi HU
;
Xing YANG
;
Anyi QIAO
;
Dacheng TANG
;
Mingjun WANG
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Chemoembolization;
Hepatic function;
Hfficacy;
Retrospective study
- From:
International Journal of Surgery
2010;37(1):28-31,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the therapeutic efficacy of transcather arterial chemoembolization for hepatic carcinoma and its influence on hepatic function. Methods Patients with HCC were divided into three groups according to repeated TACE times. The therapeutic efficacy was assessed with survival rate, car-cionma size and biologic response (AFP). Hepatic function was evaluated according to some hepatic param-eters(ALT,AST,ALB,DB,TB,PT). Results All three groups responses rates were 4.3%, 23.1% and 31.6% ;srespectively,liver function in group 1 and group 2 returned to its pretreatment level(P <0.05) ,but in group 3, liver function did not return to its pretreatment level associated with more repeated TACE times. The 1-,2-and 3-year survival rates of group 1 were 27.0%, 10.8%, 5.4% ; respectively, while those of group 2 were 57.1%, 33.3%, 19.0% ; respectively, which were not significantly different from those of Team 3 ,which was 62.5%, 37.5%, 18.8%, respectively. Conclusions (1) three to four repeated times TACE was an effective palliative treatment that prolongs survival of patients with HCC,while 1 to 2 re-peated times had a limited benefit; (2) Irreversible hepatic impairment induced by TAEC could affect its therapeutic efficacy.
