Cholecystokinin expression in hippocampus and cerebral cortex of weanling rats following heat stress and febrile convulsions
10.3760/cma.j.issn.1673-4408.2010.01.002
- VernacularTitle:热应激和热惊厥幼龄大鼠海马及大脑皮层CCK蛋白表达研究
- Author:
Hong NI
;
Daqing CHEN
;
Quanxiang SHUI
- Publication Type:Journal Article
- Keywords:
Febrile convulsion;
Heat stress;
Cholecystokinin;
Hppocampus
- From:
International Journal of Pediatrics
2010;37(1):3-5,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expression of cholecystokinin(CCK) in rat' s hippocampus and cerebral cortex following heat stress and febrile convulsions (FC). Methods Warm water was used to induce FC model. Immunohistochemistry method tested CCK protein. Results Very few or no CCK neurons were seen in the control rats. There was weaker expression of CCK in cerebral cortex of HS group,mainly located in PIR,ENT and RS subfield.No CCK positive ceiis were seen in hippocampus of HS rats. In contrast, abundant expression of CCK protein was found in hippocampus and cerebral cortex of FC group. They were well-distributed, without characteristic subnucleus-specific distribution. Conclusion Abundant induction of CCK in hippocampus and cerebral cortex of FC group suggested that CCK may play a role in the central control of FC.
