Progress of Toll-like receptors in asthma
10.3760/cma.j.issn.1673-4408.2010.03.012
- VernacularTitle:Toll样受体在哮喘中的研究进展
- Author:
Shen WANG
- Publication Type:Journal Article
- Keywords:
Toll-like receptors;
Asthma;
Immunity;
Signal transduction
- From:
International Journal of Pediatrics
2010;37(3):258-260,263
- CountryChina
- Language:Chinese
-
Abstract:
Asthma is heterogeneous disorder which caused by a complicated interaction between multiple genes and environmental factors. A increasing number of attention has paid in the researches about its pathogenic mechanism and therapeutic strategies. Not only can Toll-like receptors and signal transduction pathways mediate relevant immunocyte of asthma, but also induce or restrain development of asthma. TLRs is a land of pattern recognition receptor(PRRs), which can rely on the conserved sequence of gene encoding to identify pathogenic microorganism, meanwhile activate innate immunity,adjust acquired immunity and induce immune tolerance.
