Treatment of Hyperpigmented Disease with 4-Isopropylcatechol.
- Author:
Dong Gil BYUN
;
Joung Hoe KIM
;
Yang Ja PARK
;
Soon Bok LEE
- Publication Type:Clinical Trial ; Original Article
- MeSH:
Cafe-au-Lait Spots;
Humans;
Hyperpigmentation;
Melanins;
Melanocytes;
Melanosis;
Pigmentation
- From:Korean Journal of Dermatology
1975;13(1):5-7
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Disfiguring hyperpigmentation of the exposed areas may have impartant and lasting effects on the emotional well-being of the patient. And many attempts to treat areas of hyperpigmentation have been earried out, but all of them are not very successful. Recently 4-isopropylcatechol has been known to inhibit melanin pigmentation with a selective action on melanocytes either destroying or inactivating the melanocytes experimentally. There is no report on its clinical trial till now. In this study, 1% 4-isopropylcatechol cream was topieally applied to the hyperpigmented lesions of 29 patieots of melasma, freckle, and cafe-au-lait spot. The bleaching effect on meiasmas was very satisfactory in all patients but coantact dermatltis in 3 patients and reticular hyperpigmentation with areas of depigmented spots in one patient were developed as the side effects of the drug. Freckle and cafe-au-Iait spots were not bleached.
