Study progression of GLP-1 analogues in type 1 diabetes and islet transplant

VernacularTitle:GLP-1类似物在1型糖尿病和胰岛移植中的研究进展
Author: Xin SU ; Zhiguang ZHOU
Publication Type:Journal Article
Keywords: Glucagon-like peptide-1 analogue; Diabetes mellitus,type 1; Islet transplant; Liraglutide
From: Chinese Journal of Endocrinology and Metabolism 2010;26(7):-
CountryChina
Language:Chinese
Abstract: Type 1 diabetes mellitus (TlDM) is an autoimmune disease characterized by the destruction of pancreatic β cells, which sequentially leading to the reduction of insulin secretion. Numerous susceptibilities, including genetic and environmental factors, may be involved in triggering the T1DM. The ideal therapy for T1DM should focus on both preventing the immune system from attacking β cells, and also the stimulation of β cell neogenesis. In vitro and in vivo studies both demonstrated that GLP-1 analogues were able to promote the synthesis and secretion of insulin, stimulate neogenesis of β cells, increase β cells replication, and reduce β cell apoptosis. Hence, GLP-1 analogues have been shown to be potential treatment for T1DM. This work reviewed recent publications regarding to GLP-1 application in TlDM and pancreatic islet transplantations and prospected the future research directions.