Expression of transcriptional factor Snail and adhesion factor E-cadherin in rectal cancer
10.3760/cma.j.issn.1673-4203.2010.08.005
- VernacularTitle:转录因子Snail及黏附分子E-cadherin在直肠癌中的表达及意义
- Author:
Shuai XIAO
;
Zhengjun QIU
;
Chen HUANG
;
Feng LI
;
Longfei LIU
;
Xianzhou LU
- Publication Type:Journal Article
- Keywords:
Rectal cancer;
E-cadherin;
Snail;
Neoplasm metastasis
- From:
International Journal of Surgery
2010;37(8):514-519,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of E-cadherin and Snail proteins in rectal cancer and their significance. Methods The expression of Snail and E-cadherin proteins was detected using immunohistochemical SABC method in 101 cases of rectal cancer tissues. Results The positive rate of Snail in rectal cancer was 78.2% (79/101). The negative expression rate of E-cadherin in rectal cancer was 62.4% (63/101). The expression of Snail and E-cadherin were significantly related with the lymph node metastasis and Dukes' stage of rectal cancer (P ＜ 0.05). Conclusion The overexpression of Snail and the decreased expression of E-cadherin might be important biological markers for malignant transformation, invasion and metastasis of rectal carcinoma.
