Expression of P21ras and PIK3CA in human tissues of hepatocellular carcinoma and hepatic cirrhosis
10.3760/cma.j.issn.1673-4203.2010.08.004
- VernacularTitle:P21ras、PIK3CA在肝癌与肝硬化中的表达及意义
- Author:
Pengfei ZHENG
;
Yumin LI
;
Xun LI
;
Shiyuan LIU
;
Quanbao ZHANG
;
Wenting HE
;
Tao LIU
- Publication Type:Journal Article
- Keywords:
P21 ras protein;
Phosphatidylinositol-3 kinase catalytic alpha;
Hepatitis B virus-related hepatocellular carcinoma;
Post-hepatitis B hepatic cirrhosis
- From:
International Journal of Surgery
2010;37(8):511-514,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of P21ras and PIK3CA proteins in hepatitis B virus-related hepatocellular carcinoma(HBV-HCC), post-hepatitis B hepatic cirrhosis (HBV-hepatic cirrhosis)and normal hepatic tissues specimen, and their correlation between HBV-HCC and HBV-hepatic cirrhosis tissues.Methods Using immunohistochemistry, the expression of P21ras and PIK3CA proteins in 34 cases of HBV-HCC, 37 cases of HBV-hepatic cirrhosis and 30 cases of normal liver tissues specimen were detected and compared. Results The mean gray scales of P21ras protein in HBV-HCC, HBV-hepatic cirrhosis and normal hepatic tissue specimen were 138.86 ± 2.9, 145. 34 ± 2.06 and 152.07 ± 1.17 (P ＜ 0. 0l), respectively, and were related to the progression of hepatopathy (P ＜0.01). The mean gray scales of PIK3CA protein in HBV-HCC, HBV-hepatic cirrhosis and normal hepatic tissue specimen were 138.20 ± 3. 14, 149.49 ±0. 78 and 154.71 ± 1.29 (P ＜ 0.01), respectively, and were related to the progression of hepatopathy (P ＜ 0. 01).There were apparent correlation between P21ras and PIK3CA in HBV-HCC and HBV-hepatic cirrhosis respectively (r =0. 64, P ＜0. 05; r =0. 42, P ＜0. 05). Conclusion The overexpression of P21ras and PIK3CA in HCC and hepatic cirrhosis tissue suggests that they participate in the tumorigenesis and development of hepatocellular carcinoma and hepatic cirrhosis, and there may be a signal transduction pathway of P21ras-PI3K in HBV-HCC and HBV-hepatic cirrhosis.
